Toxoplasma and Plasmodium protein kinases: Roles in invasion and host cell remodelling
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Saeji_Toxoplasma.pdf
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Author(s)
Cooke, Brian M.
Doerig, Christian
Lim, Daniel Cham-Chin
Saeij, Jeroen
Date Issued
December 2011
Journal
International Journal for Parasitology
Publisher
Elsevier
Citation
Lim, Daniel C., Brian M. Cooke, Christian Doerig, and Jeroen P.J. Saeij. “Toxoplasma and Plasmodium Protein Kinases: Roles in Invasion and Host Cell Remodelling.” International Journal for Parasitology 42, no. 1 (January 2012): 21–32.
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Author's final manuscript
Abstract
Some apicomplexan parasites have evolved distinct protein kinase families to modulate host cell structure and function. Toxoplasma gondii rhoptry protein kinases and pseudokinases are involved in virulence and modulation of host cell signalling. The proteome of Plasmodium falciparum contains a family of putative kinases called FIKKs, some of which are exported to the host red blood cell and might play a role in erythrocyte remodelling. In this review we will discuss kinases known to be critical for host cell invasion, intracellular growth and egress, focusing on (i) calcium-dependent protein kinases and (ii) the secreted kinases that are unique to Toxoplasma (rhoptry protein kinases and pseudokinases) and Plasmodium (FIKKs).
MIT Department
Massachusetts Institute of Technology. Department of Biology
Koch Institute for Integrative Cancer Research at MIT
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DOI of Published Version
https://doi.org/10.1016/j.ijpara.2011.11.007
