Effects of Monofunctional Platinum Agents on Bacterial Growth: A Retrospective Study
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Author(s)
Alexander, Sarah M.
Lin, Wei
Lippard, Stephen J.
Johnstone, Timothy
Date Issued
December 2013
Journal
Journal of the American Chemical Society
Publisher
American Chemical Society (ACS)
Citation
Johnstone, Timothy C., Sarah M. Alexander, Wei Lin, and Stephen J. Lippard. “Effects of Monofunctional Platinum Agents on Bacterial Growth: A Retrospective Study.” Journal of the American Chemical Society 136, no. 1 (January 8, 2014): 116–118.
Version
Author's final manuscript
Abstract
The effect of the novel and potent monofunctional platinum(II) agent phenanthriplatin on Escherichia coli and bacteriophage λ lysogens is reported. E. coli filamentation was observed by light microscopy when cells were grown in the presence of phenanthriplatin, cis-[Pt(NH[subscript 3])[subscript 2](Am)Cl][superscript +] where Am is phenanthridine. Treatment of lysogenic bacteria with this compound resulted in lysis and the production of viral particles, as indicated by plaque formation in a bacterial lawn. The results obtained with phenanthriplatin are contextualized by comparison with those obtained using cisplatin as well as other, less active, monofunctional compounds such as [Pt(NH[subscript 3])[subscript 3]Cl][superscript +] and cis-[Pt(NH3)2(py)Cl]+, where py is pyridine. The ability of phenanthriplatin to induce bacterial filamentation and initiate lysis in lysogenic bacteria corroborates the hypothesis that the biological activity of this complex is mediated by its interaction with DNA.
MIT Department
Massachusetts Institute of Technology. Department of Chemistry
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Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
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DOI of Published Version
https://doi.org/10.1021/ja411742c
