Repeat dose NRPT (nicotinamide riboside and pterostilbene) increases NAD+ levels in humans safely and sustainably: a randomized, double-blind, placebo-controlled study
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Author(s)
Dellinger, Ryan W.
Santos, Santiago Roel
Morris, Mark
Evans, Mal
Alminana, Dan
Marcotulli, Eric
Guarente, Leonard Pershing
Date Issued
November 2017
Journal
npj Aging and Mechanisms of Disease
Publisher
Springer Nature
Citation
Dellinger, Ryan W. et al. “Repeat Dose NRPT (nicotinamide Riboside and Pterostilbene) Increases NAD+ Levels in Humans Safely and Sustainably: a Randomized, Double-Blind, Placebo-Controlled Study.” Npj Aging and Mechanisms of Disease 3, 1 (November 2017): 17 © 2017 The Author(s)
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Final published version
Abstract
NRPT is a combination of nicotinamide riboside (NR), a nicotinamide adenine dinucleotide (NAD⁺) precursor vitamin found in milk, and pterostilbene (PT), a polyphenol found in blueberries. Here, we report this first-in-humans clinical trial designed to assess the safety and efficacy of a repeat dose of NRPT (commercially known as Basis). NRPT was evaluated in a randomized, double-blind, and placebo-controlled study in a population of 120 healthy adults between the ages of 60 and 80 years. The study consisted of three treatment arms: placebo, recommended dose of NRPT (NRPT 1X), and double dose of NRPT (NRPT 2X). All subjects took their blinded supplement daily for eight weeks. Analysis of NAD⁺ in whole blood demonstrated that NRPT significantly increases the concentration of NAD⁺ in a dose-dependent manner. NAD⁺ levels increased by approximately 40% in the NRPT 1X group and approximately 90% in the NRPT 2X group after 4 weeks as compared to placebo and baseline. Furthermore, this significant increase in NAD⁺ levels was sustained throughout the entire 8-week trial. NAD⁺ levels did not increase for the placebo group during the trial. No serious adverse events were reported in this study. This study shows that a repeat dose of NRPT is a safe and effective way to increase NAD⁺ levels sustainably.
MIT Department
Massachusetts Institute of Technology. Department of Biology
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DOI of Published Version
https://doi.org/10.1038/S41514-017-0016-9
