7.341 DNA Damage Checkpoints: The Emergency Brake on the Road to Cancer, Fall 2007
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7-341Fall-2007/OcwWeb/Biology/7-341Fall-2007/CourseHome/index.htm
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Checksum (MD5)
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Author(s)
Reinhardt, Hans Christian
van Vugt, Marcel A.
Alternative Title
DNA Damage Checkpoints: The Emergency Brake on the Road to Cancer
Date Issued
December 2007
Abstract
The DNA contained in human cells is under constant attack by both exogenous and endogenous agents that can damage one of its three billion base pairs. To cope with this permanent exposure to DNA-damaging agents, such as the sun's radiation or by-products of our normal metabolism, powerful DNA damage checkpoints have evolved that allow organisms to survive this constant assault on their genomes. In this class we will analyze classical and recent papers from the primary research literature to gain a profound understanding of checkpoints that act as powerful emergency brakes to prevent cancer. We will consider basic principles of cell proliferation and molecular details of the DNA damage response. We will discuss the methods and model organisms typically used in this field as well as how an understanding of checkpoint mechanisms translates into the development of treatments for human cancer. This course will not stop at discussing literature. We will take it one step further and analyze real data in an MIT Biology laboratory. This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at MIT. These seminars are tailored for students with an interest in using primary research literature to discuss and learn about current biological research in a highly interactive setting. Many instructors of the Advanced Undergraduate Seminars are postdoctoral scientists with a strong interest in teaching.
Subjects
DNA
damage checkpoints
cancer
cells
human cells
exogenous
endogenous
checkpoints
gene
signaling
cancer biology
cancer prevention
primary sources
discussion
DNA damage
molecular
enzyme
cell cycle
extracellular cues
growth factors
Cdk regulation
cyclin-dependent kinase
p53
tumor suppressor
apoptosis
signaling
MDC1
H2AX
Rad50
Fluorescence activated cell sorter
Chk1
mutant
MIT Department
Massachusetts Institute of Technology. Department of Biology
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