N‐Heterocyclic Carbene‐Based Copolymers for Templated Synthesis and Stabilization of Gold Nanoparticles
Name
Chemistry A European J - 2025 - Nguyen - N‐Heterocyclic Carbene‐Based Copolymers for Templated Synthesis and Stabilization.pdf
Size
54.24 MB
Format
Adobe PDF
Checksum (MD5)
6f2dfa8486e548ea428e0b6848ac559a
Author(s)
Nguyen, Suong T.
Brown, Christopher M.
Zhang, Wenxu
Kilgallon, Landon J.
Johnson, Jeremiah A.
Date Issued
February 17, 2025
Journal
Chemistry – A European Journal
Publisher
Wiley
Citation
S. T. Nguyen, C. M. Brown, W. Zhang, L. J. Kilgallon, J. A. Johnson, Chem. Eur. J. 2025, 31, e202500596.
Version
Final published version
Abstract
Surface functionalization and colloidal stability are pivotal for numerous applications of gold nanoparticles (Au-NPs). Over the past decade, N-heterocyclic carbenes (NHCs) have emerged as promising ligands for stabilizing Au-NPs owing to their ease of synthesis, structural diversity, and strong metal-ligand bonds. Here, we introduce new Au(I)–NHCcopolymer scaffolds as precursors to multidentate NHC-protected Au-NPs. Ring-opening metathesis copolymerization of a norbornene-appended Au(I)−NHC complex with another functionalized norbornene comonomer provides NHC–Au(I) copolymers with modular compositions and structures. Upon reduction, these copolymers yield multidentate polyNHC-coated Au-NPs with varied properties and corona functionalities dictated by the secondary monomer. These nanoparticles exhibit excellent size homogeneity and stability against aggregation in various buffers, cell culture media, and under exposure to electrolytes, oxidants, and exogenous thiols over extended periods. Moreover, we demonstrate post-synthetic surface functionalization reactions of polyNHC−Au-NPs while maintaining colloidal stability, highlighting their robustness and potential for applications such as bioconjugation. Overall, these findings underscore the potential of ROMP-derived NHC-containing copolymers as highly tunable and versatile multidentate ligands that may be suitable for other inorganic colloids and flat surfaces.
MIT Department
Massachusetts Institute of Technology. Department of Chemistry
Koch Institute for Integrative Cancer Research at MIT
Terms of Use
Creative Commons Attribution
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1002/chem.202500596
