The Definition, Rationale, and Effects of Thresholding in OCT Angiography
Name
nihms866395.pdf
Description
Accepted version
Size
2.49 MB
Format
Adobe PDF
Checksum (MD5)
2bc83b4fe93e1c21366ff5871bfb5169
Author(s)
Cole, Emily D.
Moult, Eric Michael
Dang, Sabin
Choi, Woo Jhon
Ploner, Stefan B
Lee, ByungKun
Louzada, Ricardo
Novais, Eduardo
Schottenhamml, Julia Jennifer
Maier, Andreas
Date Issued
September 2017
Journal
Ophthalmology Retina
Publisher
Elsevier BV
Citation
Cole, Emily D., et al. “The Definition, Rationale, and Effects of Thresholding in OCT Angiography.” Ophthalmology Retina 1, no. 5 (September 2017): 435–47.
Version
Author's final manuscript
Abstract
PURPOSE: To examine the definition, rationale, and effects of thresholding in OCT angiography (OCTA). DESIGN: A theoretical description of OCTA thresholding in combination with qualitative and quantitative analysis of the effects of OCTA thresholding in eyes from a retrospective case series. PARTICIPANTS: Four eyes were qualitatively examined: 1 from a 27-year-old control, 1 from a 78-year-old exudative age-related macular degeneration (AMD) patient, 1 from a 58-year-old myopic patient, and 1 from a 77-year-old nonexudative AMD patient with geographic atrophy (GA). One eye from a 75-year-old nonexudative AMD patient with GA was quantitatively analyzed. MAIN OUTCOME MEASURES: A theoretical thresholding model and a qualitative and quantitative description of the dependency of OCTA on thresholding level. RESULTS: Due to the presence of system noise, OCTA thresholding is a necessary step in forming OCTA images; however, thresholding can complicate the relationship between blood flow and OCTA signal. CONCLUSIONS: Thresholding in OCTA can cause significant artifacts, which should be considered when interpreting and quantifying OCTA images.
MIT Department
Harvard University--MIT Division of Health Sciences and Technology
Massachusetts Institute of Technology. Institute for Medical Engineering & Science
Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science
Terms of Use
Creative Commons Attribution-NonCommercial-NoDerivs License
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1016/J.ORET.2017.01.019
