Dendrimer-Au nanoparticle network covered alumina membrane for ion rectification and enhanced bioanalysis
Name
acs.nanolett.9b05066.pdf
Description
Published version
Size
4.5 MB
Format
Adobe PDF
Checksum (MD5)
63578d382bad14a02ba20789a8cab508
Author(s)
Wang, Chen
Zhao, Xiao-Ping
Liu, Fei-Fei
Chen, Yuming
Xia, Xing-Hua
Li, Ju
Date Issued
February 2020
Journal
Nano letters
Publisher
American Chemical Society (ACS)
Citation
Wang, Chen, et al., "Dendrimer-Au nanoparticle network covered alumina membrane for ion rectification and enhanced bioanalysis." Nano letters 20, 3 (2020): p. 1846-54 doi 10.1021/acs.nanolett.9b05066 ©2020 Author(s)
Version
Final published version
Abstract
Ion transport in an artificial asymmetric nanoporous membrane, which is similar to biological ion channels, can be used for biosensing. Here, a dendrimer-Au nanoparticle network (DAN) is in situ assembled on a nanoporous anodic aluminum oxide (AAO) surface, forming a DAN/AAO hybrid membrane. Benefiting from the high surface area and anion selectivity of DAN, the prepared DAN/AAO hybrid presents selective ion transport. Under a bias potential, a diode-like current-potential (I-V) response is observed. The obtained ionic current rectification (ICR) property can be tuned by the ion valence and pH value of the electrolyte. The rectified ionic current endows the as-prepared DAN/AAO hybrid with the ability of enhanced bioanalysis. Sensitive capture and detection of circulating tumor cells (CTCs) with a detection limit of 80 cells mL-1 as well as excellent reusability can be achieved. ©2020 keywords: dendrimer-Au nanoparticle network; hybrid membrane; ion selectivity; ionic current rectification; enhanced bioanalysis
MIT Department
Massachusetts Institute of Technology. Department of Materials Science and Engineering
Terms of Use
Creative Commons Attribution 4.0 International license
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DOI of Published Version
https://doi.org/10.1021/acs.nanolett.9b05066
