Studying host-pathogen interactions and innate immunity in Caenorhabditis elegans
Name
Kim-2008-Studying host-pathogen interactions and innate immunity in Caenorhabditis elegans.pdf
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261.29 KB
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Author(s)
Kim, Dennis H.
Date Issued
December 2008
Journal
Disease Models and Mechanisms
Publisher
Company of Biologists
Citation
Kim, D. “Studying Host-pathogen Interactions and Innate Immunity in Caenorhabditis Elegans.” Disease Models and Mechanisms 1.4-5 (2008): 205–208. Copyright © 2008 Published by The Company of Biologists Ltd
Version
Final published version
Abstract
The genetic analysis of mechanisms of pathogen resistance in the nematode Caenorhabditis elegans has revealed a role for evolutionarily conserved signaling pathways that are required for innate immunity in a wide range of organisms, from worms to mammals. C. elegans represents one of the more simple host organisms in which mechanisms of host defense can be dissected, and the use of C. elegans presents the researcher with a wide array of genetic and genomic tools to probe the host-pathogen interface. The study of host defense mechanisms in C. elegans continues to provide an ancient evolutionary perspective on innate immunity, which may generate insights into the conserved processes in phylogenetically diverse host organisms, including humans.
MIT Department
Massachusetts Institute of Technology. Department of Biology
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Creative Commons Attribution-Noncommercial-Share Alike 3.0
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DOI of Published Version
https://doi.org/10.1242/dmm.000265
