Global Analysis of the Specificities and Targets of Endoribonucleases from Escherichia coli Toxin-Antitoxin Systems
Name
mBio.02012-21.pdf
Description
Published version
Size
4.42 MB
Format
Adobe PDF
Checksum (MD5)
7930128961cd55b3701ccd84b9bb9f4f
Author(s)
Culviner, Peter H
Nocedal, Isabel
Fortune, Sarah M
Laub, Michael T
Date Issued
2021
Journal
mBio
Publisher
American Society for Microbiology
Citation
Culviner, Peter H, Nocedal, Isabel, Fortune, Sarah M and Laub, Michael T. 2021. "Global Analysis of the Specificities and Targets of Endoribonucleases from Escherichia coli Toxin-Antitoxin Systems." mBio, 12 (5).
Version
Final published version
Abstract
Toxin-antitoxin (TA) systems are widespread genetic modules found in almost all bacteria that can regulate their growth and may play prominent roles in phage defense. Escherichia coli encodes 11 TA systems in which the toxin is a known or predicted endoribonuclease. The targets and cleavage specificities of these endoribonucleases have remained largely uncharacterized, precluding an understanding of how each impacts cell growth and an assessment of whether they have distinct or overlapping targets.
Toxin-antitoxin (TA) systems are widespread genetic modules found in almost all bacteria that can regulate their growth and may play prominent roles in phage defense. Escherichia coli encodes 11 TA systems in which the toxin is a known or predicted endoribonuclease. The targets and cleavage specificities of these endoribonucleases have remained largely uncharacterized, precluding an understanding of how each impacts cell growth and an assessment of whether they have distinct or overlapping targets.
MIT Department
Massachusetts Institute of Technology. Department of Biology
Terms of Use
Creative Commons Attribution 4.0 International license
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DOI of Published Version
https://doi.org/10.1128/MBIO.02012-21
