Liposomes for HIV prophylaxis
Name
nihms-346721.pdf
Description
Accepted version
Size
980.82 KB
Format
Adobe PDF
Checksum (MD5)
b1d6513cd9b8a19c210ef71e0a03e36c
Author(s)
Malavia, Nikita K
Zurakowski, David
Schroeder, Avi
Princiotto, Amy M
Laury, Anna R
Barash, Hila E
Sodroski, Joseph
Langer, Robert
Madani, Navid
Kohane, Daniel S
Date Issued
2011
Journal
Biomaterials
Publisher
Elsevier BV
Citation
Malavia, N. K., et al. "Liposomes for Hiv Prophylaxis." Biomaterials (2011).
Version
Author's final manuscript
Abstract
There are approximately 33.4 million adults living with HIV worldwide of which an estimated 15.7 million are women. Although there has been enormous progress in the therapy of HIV/AIDS, treatment is not curative. Prevention is therefore of paramount importance, but vaccine-based and microbicidal approaches are still in their infancy. Since women acquire the virus largely through sexual intercourse, we developed liposomal systems potentially suitable for intra-vaginal use to prevent HIV-1 infection. We formulated liposomes from a range of naturally-occurring and synthetic lipids with varying physicochemical properties, and tested their ability to inhibit infection of transformed cells that express receptors specific to the virus. We identified formulations with the most favorable balance between decreasing HIV infection and causing cytotoxicity (i.e. therapeutic index). The therapeutic index improved with increasing cardiolipin content, and degree of unsaturation. Tissue reaction to these formulations was benign after intra-vaginal instillation in an in vivo female mouse model. These results support the potential use of cardiolipin-based liposomes enriched with synthetic lipids as microbicides for the prevention of HIV infection in women. © 2011 Elsevier Ltd.
MIT Department
Massachusetts Institute of Technology. Department of Chemical Engineering
Terms of Use
Creative Commons Attribution-NonCommercial-NoDerivs License
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1016/j.biomaterials.2011.07.068
