Computational tools for modeling and measuring chromosome structure
Name
846592515-MIT.pdf
Description
Full printable version
Size
9 MB
Format
Adobe PDF
Checksum (MD5)
2f14585abd7ef10c2e1905e7cdc6d153
Author(s)
Ross, Brian Christopher
Advisor(s)
Alexander van Oudenaarden and Paul Wiggins.
Date Issued
2012
Publisher
Massachusetts Institute of Technology
Abstract
DNA conformation within cells has many important biological implications, but there are challenges both in modeling DNA due to the need for specialized techniques, and experimentally since tracing out in vivo conformations is currently impossible. This thesis contributes two computational projects to these efforts. The first project is a set of online and offline calculators of conformational statistics using a variety of published and unpublished methods, addressing the current lack of DNA model-building tools intended for general use. The second project is a reconstructive analysis that could enable in vivo mapping of DNA conformation at high resolution with current experimental technology.
Description
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Physics, 2012.
Cataloged from PDF version of thesis.
Includes bibliographical references (p. 99-112).
Subjects
Physics.
MIT Department
Massachusetts Institute of Technology. Department of Physics
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copyright. They may be viewed from this source for any purpose, but
reproduction or distribution in any format is prohibited without written
permission. See provided URL for inquiries about permission.
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