Physiome-on-a-Chip: The Challenge of “Scaling” in Design, Operation, and Translation of Microphysiological Systems
Name
Physiome-on-a-Chip.pdf
Size
189.1 KB
Format
Adobe PDF
Checksum (MD5)
d922549f6c6681c4bae4d7cbb76a2ad8
Author(s)
Stokes, CL
Lauffenburger, Douglas A
Cirit, Murat
Date Issued
September 2015
Journal
CPT: Pharmacometrics & Systems Pharmacology
Publisher
Nature Publishing Group
Citation
Stokes, Cl, M Cirit, and Da Lauffenburger. “Physiome-on-a-Chip: The Challenge of ‘Scaling’ in Design, Operation, and Translation of Microphysiological Systems: Physiome-on-a-Chip.” CPT: Pharmacometrics & Systems Pharmacology 4.10 (2015): 559–562.
Version
Final published version
Abstract
Scaling of a microphysiological system (MPS) or physiome-on-a-chip is arguably two interrelated, modeling-based activities: on-platform scaling and in vitro-in vivo translation. This dual approach reduces the need to perfectly rescale and mimic in vivo physiology, an aspiration that is both extremely challenging and not substantively meaningful because of uncertain relevance of any specific physiological condition. Accordingly, this perspective offers a tractable approach for designing interacting MPSs and relating in vitro results to analogous context in vivo.
MIT Department
Massachusetts Institute of Technology. Department of Biological Engineering
Terms of Use
Creative Commons Attribution 4.0 International License
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1002/psp4.12042
