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Commensal epitopes drive differentiation of colonic T regs
Name
sciadv.aaz3186.pdf
Description
Published version
Size
2.91 MB
Format
Adobe PDF
Checksum (MD5)
5b9358487e27f9cabab65231792aebe1
Author(s)
Kuczma, Michal P
Szurek, Edyta A
Cebula, Anna
Chassaing, Benoit
Jung, Yu-Jin
Kang, Sang-Moo
Fox, James G
Stecher, Bärbel
Ignatowicz, Leszek
Date Issued
2020
Journal
Science Advances
Publisher
American Association for the Advancement of Science (AAAS)
Version
Final published version
Abstract
© 2020 The Authors. The gut microbiome is the largest source of intrinsic non-self-antigens that are continuously sensed by the immune system but typically do not elicit lymphocyte responses. CD4+ T cells are critical to sustain uninterrupted tolerance to microbial antigens and to prevent intestinal inflammation. However, clinical interventions targeting commensal bacteria-specific CD4+ T cells are rare, because only a very limited number of commensal-derived epitopes have been identified. Here, we used a new approach to study epitopes and identify T cell receptors expressed by CD4+Foxp3+ (Treg) cells specific for commensal-derived antigens. Using this approach, we found that antigens from Akkermansia muciniphila reprogram naïve CD4+ T cells to the Treg lineage, expand preexisting microbe specific Tregs, and limit wasting disease in the CD4+ T cell transfer model of colitis. These data suggest that the administration of specific commensal epitopes may help to widen the repertoire of specific Tregs that control intestinal inflammation.
Terms of Use
Creative Commons Attribution NonCommercial License 4.0
Persistent DSpace Link
DOI of Published Version
10.1126/SCIADV.AAZ3186
