RNA in formation and regulation of transcriptional condensates
Name
52.full.pdf
Description
Published version
Size
3.57 MB
Format
Adobe PDF
Checksum (MD5)
02d4d48849c777f26639afbb994b1c3f
Author(s)
Sharp, Phillip A
Chakraborty, Arup K
Henninger, Jonathan E
Young, Richard A
Date Issued
2022
Journal
RNA
Publisher
Cold Spring Harbor Laboratory
Citation
Sharp, Phillip A, Chakraborty, Arup K, Henninger, Jonathan E and Young, Richard A. 2022. "RNA in formation and regulation of transcriptional condensates." RNA, 28 (1).
Version
Final published version
Abstract
Macroscopic membraneless organelles containing RNA such as the nucleoli, germ granules, and the Cajal body have been known for decades. These biomolecular condensates are liquid-like bodies that can be formed by a phase transition. Recent evidence has revealed the presence of similar microscopic condensates associated with the transcription of genes. This brief article summarizes thoughts about the importance of condensates in the regulation of transcription and how RNA molecules, as components of such condensates, control the synthesis of RNA. Models and experimental data suggest that RNAs from enhancers facilitate the formation of a condensate that stabilizes the binding of transcription factors and accounts for a burst of transcription at the promoter. Termination of this burst is pictured as a nonequilibrium feedback loop where additional RNA destabilizes the condensate.
MIT Department
Massachusetts Institute of Technology. Department of Biology
Terms of Use
Creative Commons Attribution NonCommercial License 4.0
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1261/RNA.078997.121
