Compromised SARS-CoV-2-specific placental antibody transfer
Name
1-s2.0-S0092867420317499-main.pdf
Size
6.26 MB
Format
Adobe PDF
Checksum (MD5)
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Author(s)
Atyeo, Caroline
Pullen, Krista M.
Bordt, Evan A.
Fischinger, Stephanie
Burke, John
Michell, Ashlin
Slein, Matthew D.
Loos, Carolin
Shook, Lydia L.
Boatin, Adeline A.
Date Issued
December 2020
Journal
Cell
Publisher
Elsevier BV
Citation
Atyeo, Caroline et al. "Compromised SARS-CoV-2-specific placental antibody transfer." Cell 184, 3 (February 2021): P628-642.e10 © 2020 The Author(s)
Version
Final published version
Abstract
SARS-CoV-2 infection causes more severe disease in pregnant women compared to age-matched non-pregnant women. Whether maternal infection causes changes in the transfer of immunity to infants remains unclear. Maternal infections have previously been associated with compromised placental antibody transfer, but the mechanism underlying this compromised transfer is not established. Here, we used systems serology to characterize the Fc profile of influenza-, pertussis-, and SARS-CoV-2-specific antibodies transferred across the placenta. Influenza- and pertussis-specific antibodies were actively transferred. However, SARS-CoV-2-specific antibody transfer was significantly reduced compared to influenza- and pertussis-specific antibodies, and cord titers and functional activity were lower than in maternal plasma. This effect was only observed in third-trimester infection. SARS-CoV-2-specific transfer was linked to altered SARS-CoV-2-antibody glycosylation profiles and was partially rescued by infection-induced increases in IgG and increased FCGR3A placental expression. These results point to unexpected compensatory mechanisms to boost immunity in neonates, providing insights for maternal vaccine design.
MIT Department
Massachusetts Institute of Technology. Department of Biological Engineering
Terms of Use
Creative Commons Attribution 4.0 International license
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1016/j.cell.2020.12.027
