Continuous-flow synthesis and purification of atropine with sequential in-line separations of structurally similar impurities
Name
J Flow Chem, 2015, 5, 133-138..pdf
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883.86 KB
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Checksum (MD5)
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Author(s)
Dai, Chunhui
Snead, David
Zhang, Ping
Jamison, Timothy F.
Date Issued
April 2015
Journal
Journal of Flow Chemistry
Publisher
Akadémiai Kiadó Zrt.
Citation
Dai, Chunhui, David R. Snead, Ping Zhang, and Timothy F. Jamison. “Continuous-Flow Synthesis and Purification of Atropine with Sequential in-Line Separations of Structurally Similar Impurities.” Journal of Flow Chemistry 5, no. 3 (September 2015): 133–138.
Version
Author's final manuscript
Abstract
Flow chemistry has attracted significant interest in pharmaceutical development, where substantial efforts have been directed toward the design of continuous processes. Here, we report a total synthesis of atropine in flow that features an unusual hydroxymethylation and separation of several byproducts with high structural similarity to atropine. Using a combination of careful pH control in three sequential liquid-liquid extractions and a functionalized resin, atropine is delivered by the flow system with >98% purity.
MIT Department
Massachusetts Institute of Technology. Department of Chemistry
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Creative Commons Attribution-Noncommercial-Share Alike
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DOI of Published Version
https://doi.org/10.1556/1846.2015.00013
