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The Ups and Downs of the Striatum: Dopamine Biases Upstate Balance of Striosomes and Matrix

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Graybiel and Matsushima (2020) Neuron.pdf

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Author(s)
Graybiel, Ann M
•
Matsushima, Ayano
Date Issued
2020
Journal
Neuron
Publisher
Elsevier BV
Citation
Graybiel, Ann M and Matsushima, Ayano. 2020. "The Ups and Downs of the Striatum: Dopamine Biases Upstate Balance of Striosomes and Matrix." Neuron, 108 (6).
Version
Author's final manuscript
Abstract
© 2020 Elsevier Inc. Prager et al. demonstrate an opposite regulation of activity in striosomes and matrix of the striatum. By a D1-receptor-linked L-VGCC-dependent mechanism, dopamine release can extend upstates in matrix D1-expressing projection neurons (dSPNs) but shorten them in striosomal dSPNs.
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DOI of Published Version
10.1016/J.NEURON.2020.11.025
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