Continuous Flow Coupling and Decarboxylation Reactions Promoted by Copper Tubing
Name
YZ TFJ SJP NM Org Lett 2011.pdf
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644.07 KB
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Author(s)
Zhang, Yun
Jamison, Timothy F.
Patel, Sejal
Mainolfi, Nello
Date Issued
December 2010
Journal
Organic Letters
Publisher
American Chemical Society (ACS)
Citation
Zhang, Yun et al. “Continuous Flow Coupling and Decarboxylation Reactions Promoted by Copper Tubing.” Organic Letters 13.2 (2011): 280–283.
Version
Author's final manuscript
Abstract
A convenient and efficient flow method for Ullmann condensations, Sonogashira couplings, and decarboxylation reactions using a commercially available copper tube flow reactor (CTFR) is described. The heated CTFR effects these transformations without added metals (e.g., Pd), ligands, or reagents, and in greater than 90% yield in most cases examined.
MIT Department
Massachusetts Institute of Technology. Department of Chemistry
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Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
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DOI of Published Version
https://doi.org/10.1021/ol1026848
