Nanoparticles that communicate in vivo to amplify tumour targeting
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Bhatia_Nanoparticles that.pdf
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Author(s)
Park, Ji-Ho
Lin, Kevin Yu-Ming
Singh, Neetu
Schwöppe, Christian
Mesters, Rolf
Berdel, Wolfgang E.
Ruoslahti, Erkki
Sailor, Michael J.
von Maltzhan, Geoffrey
Bhatia, Sangeeta N
Date Issued
June 2011
Journal
Nature Materials
Publisher
Nature Publishing Group
Citation
Von Maltzahn, Geoffrey et al. “Nanoparticles That Communicate in Vivo to Amplify Tumour Targeting.” Nature Materials 10.7 (2011): 545–552. © 2011 Macmillan Publishers Limited
Version
Author's final manuscript
Abstract
Nanomedicines have enormous potential to improve the precision of cancer therapy, yet our ability to efficiently home these materials to regions of disease in vivo remains very limited. Inspired by the ability of communication to improve targeting in biological systems, such as inflammatory-cell recruitment to sites of disease, we construct systems where synthetic biological and nanotechnological components communicate to amplify disease targeting in vivo. These systems are composed of ‘signalling’ modules (nanoparticles or engineered proteins) that target tumours and then locally activate the coagulation cascade to broadcast tumour location to clot-targeted ‘receiving’ nanoparticles in circulation that carry a diagnostic or therapeutic cargo, thereby amplifying their delivery. We show that communicating nanoparticle systems can be composed of multiple types of signalling and receiving modules, can transmit information through multiple molecular pathways in coagulation, can operate autonomously and can target over 40 times higher doses of chemotherapeutics to tumours than non-communicating controls.
Description
Author Manuscript: 2012 May 29
MIT Department
Harvard University--MIT Division of Health Sciences and Technology
Massachusetts Institute of Technology. Department of Chemical Engineering
Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science
Koch Institute for Integrative Cancer Research at MIT
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Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
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DOI of Published Version
https://doi.org/10.1038/nmat3049
