Cell Culture on MEMS Platforms: A Review
Name
Ni-2009-Cell Culture on MEMS Platforms A Review.pdf
Size
245.01 KB
Format
Adobe PDF
Checksum (MD5)
713c1285675161e2ef3ad6b427b4ff99
Author(s)
Ni, Ming
Tong, Wen Hao
Choudhury, Deepak
Rahim, Nur Aida Abdul
Iliescu, Ciprian
Yu, Hanry
Date Issued
December 2009
Journal
International Journal of Molecular Sciences
Publisher
Molecular Diversity Preservation International
Citation
Ni, Ming et al. “Cell Culture on MEMS Platforms: A Review.” International Journal of Molecular Sciences 10.12 (2009) : 5411-5441.
Version
Final published version
Abstract
Microfabricated systems provide an excellent platform for the culture of cells, and are an extremely useful tool for the investigation of cellular responses to various stimuli. Advantages offered over traditional methods include cost-effectiveness, controllability, low volume, high resolution, and sensitivity. Both biocompatible and bioincompatible materials have been developed for use in these applications. Biocompatible materials such as PMMA or PLGA can be used directly for cell culture. However, for bioincompatible materials such as silicon or PDMS, additional steps need to be taken to render these materials more suitable for cell adhesion and maintenance. This review describes multiple surface modification strategies to improve the biocompatibility of MEMS materials. Basic concepts of cell-biomaterial interactions, such as protein adsorption and cell adhesion are covered. Finally, the applications of these MEMS materials in Tissue Engineering are presented.
MIT Department
Massachusetts Institute of Technology. Department of Biological Engineering
Massachusetts Institute of Technology. Department of Mechanical Engineering
Terms of Use
Creative Commons Attribution 3.0
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.3390/ijms10125411
