MicroRNA Functions in Stress Responses
Name
Sharp_MicroRNA functions.pdf
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1.15 MB
Format
Adobe PDF
Checksum (MD5)
4db20438d780f470677f127c73077eed
Author(s)
Leung, Anthony
Sharp, Phillip A.
Date Issued
October 2010
Journal
Molecular Cell
Publisher
Elsevier B.V.
Citation
Leung, Anthony K.L., and Phillip A. Sharp. “MicroRNA Functions in Stress Responses.” Molecular Cell 40, no. 2 (October 2010): 205-215.
Version
Final published version
Abstract
MicroRNAs (miRNAs) are a class of ~22 nucleotide short noncoding RNAs that play key roles in fundamental cellular processes, including how cells respond to changes in environment or, broadly defined, stresses. Responding to stresses, cells either choose to restore or reprogram their gene expression patterns. This decision is partly mediated by miRNA functions, in particular by modulating the amount of miRNAs, the amount of mRNA targets, or the activity/mode of action of miRNA-protein complexes. In turn, these changes determine the specificity, timing, and concentration of gene products expressed upon stresses. Dysregulation of these processes contributes to chronic diseases, including cancers.
MIT Department
Massachusetts Institute of Technology. Department of Biology
Koch Institute for Integrative Cancer Research at MIT
Terms of Use
Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1016/j.molcel.2010.09.027
