Juicer Provides a One-Click System for Analyzing Loop-Resolution Hi-C Experiments
Name
Lander_Juicer provides.pdf
Size
1.17 MB
Format
Adobe PDF
Checksum (MD5)
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Author(s)
Durand, Neva C.
Shamim, Muhammad S.
Machol, Ido
Rao, Suhas S.P.
Huntley, Miriam H.
Aiden, Erez Lieberman
Lander, Eric Steven
Date Issued
July 2016
Journal
Cell Systems
Publisher
Elsevier
Citation
Durand, Neva C. et al. “Juicer Provides a One-Click System for Analyzing Loop-Resolution Hi-C Experiments.” Cell Systems 3.1 (2016): 95–98.
Version
Final published version
Abstract
Hi-C experiments explore the 3D structure of the genome, generating terabases of data to create high-resolution contact maps. Here, we introduce Juicer, an open-source tool for analyzing terabase-scale Hi-C datasets. Juicer allows users without a computational background to transform raw sequence data into normalized contact maps with one click. Juicer produces a hic file containing compressed contact matrices at many resolutions, facilitating visualization and analysis at multiple scales. Structural features, such as loops and domains, are automatically annotated. Juicer is available as open source software at http://aidenlab.org/juicer/.
MIT Department
Massachusetts Institute of Technology. Department of Biology
Terms of Use
Creative Commons Attribution 4.0 International License
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1016/j.cels.2016.07.002
