Resolving the neural circuits of anxiety
Name
Tyemanuscript.pdf
Size
2.14 MB
Format
Adobe PDF
Checksum (MD5)
cda392aa27f1d789533a82ebe8abb71a
Author(s)
Calhoon, Gwendolyn G.
Tye, Kay
Date Issued
October 2015
Journal
Nature Neuroscience
Publisher
Nature Publishing Group
Citation
Calhoon, Gwendolyn G. and Kay M. Tye. "Resolving the neural circuits of anxiety." Nature Neuroscience 18:10 (October 2015), pp. 1394-1404.
Version
Author's final manuscript
Abstract
Although anxiety disorders represent a major societal problem demanding new therapeutic targets, these efforts have languished in the absence of a mechanistic understanding of this subjective emotional state. While it is impossible to know with certainty the subjective experience of a rodent, rodent models hold promise in dissecting well-conserved limbic circuits. The application of modern approaches in neuroscience has already begun to unmask the neural circuit intricacies underlying anxiety by allowing direct examination of hypotheses drawn from existing psychological concepts. This information points toward an updated conceptual model for what neural circuit perturbations could give rise to pathological anxiety and thereby provides a roadmap for future therapeutic development.
MIT Department
Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
Picower Institute for Learning and Memory
Terms of Use
Creative Commons Attribution-Noncommercial-Share Alike
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1038/nn.4101
