CREB regulates excitability and the allocation of memory to subsets of neurons in the amygdala
Name
Neve CREB_Regulates.pdf
Size
19.29 MB
Format
Adobe PDF
Checksum (MD5)
501faacdec52e943f2d4a21cc605771f
Author(s)
Neve, Rachael L.
Zhou, Yu
Won, Jaejoon
Karlsson, Mikael Guzman
Zhou, Miou
Rogerson, Thomas
J., Balaji
Poirazi, Panayiota
Silva, Alcino J.
Date Issued
September 2009
Journal
Nature Neuroscience
Publisher
Nature Publishing Group
Citation
Zhou, Yu et al. “CREB regulates excitability and the allocation of memory to subsets of neurons in the amygdala.” Nat Neurosci 12.11 (2009): 1438-1443. © 2009 Nature Publishing Group.
Version
Author's final manuscript
Abstract
The mechanisms that determine how information is allocated to specific
regions and cells in the brain are fundamentally important for memory
capacity, storage and retrieval, but are poorly understood. Here, we
manipulated CREB in a subset of lateral amygdala (LA) neurons with a
modified Herpes Simplex Virus (HSV), and reversibly inactivated transfected
neurons with the Drosophila allatostatin G-protein-coupled receptor
(AlstR)/ligand system. We found that inactivation of the HSV-CREB
subpopulation of neurons with allatostatin (AL) during training disrupted
memory for tone conditioning, while inactivation of a similar proportion of
HSV-LacZ control neurons did not. Whole-cell recordings of fluorescently
tagged HSV-CREB neurons revealed that neurons with higher CREB levels
are more excitable than neighboring neurons, and show larger synaptic
efficacy changes following conditioning. Our findings demonstrate that
CREB modulates the allocation of fear memory to specific cells in lateral
amygdala, and suggest that neuronal excitability plays a key role in this
process.
MIT Department
Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
Picower Institute for Learning and Memory
Terms of Use
Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1038/nn.2405
