Morphological Definition of Actin Architecture at the T Cell Immunological Synapse
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41745_2020_216_ReferencePDF.pdf
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852.43 KB
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b29cdf3e35350f57a727a8362c4f1bdd
Author(s)
Kumari, Sudha
Irvine, Darrell J
Date Issued
January 2021
Publisher
Springer India
Version
Author's final manuscript
Abstract
T lymphocytes (T cells) are the major mediators of adaptive immune response. They detect pathogens primarily via the interaction of their T cell receptor (TCR) with the cognate pathogen-derived peptide displayed in the context of MHC on the infected cell. A critical step in T cell activation is the formation of immunological synapse, a specialized cell–cell conjugate interface between the T cell and infected cell, where massive TCR-induced actin remodeling and polymerization take place. Dynamic actin polymerization at the immunological synapse is essential for T cell activation and subsequently, immune response.
MIT Department
Koch Institute for Integrative Cancer Research at MIT
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Creative Commons Attribution-Noncommercial-Share Alike
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DOI of Published Version
https://doi.org/10.1007/s41745-020-00216-y
