Radical-mediated Dimerization and Oxidation Reactions for the Synthesis of Complex Alkaloids
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Movassaghi_Radical-mediated.pdf
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3.99 MB
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Adobe PDF
Checksum (MD5)
9360133a90ecb5c1310d0d9c0da77afd
Author(s)
Lathrop, Stephen
Kim, Justin
Movassaghi, Mohammad
Date Issued
June 2012
Journal
CHIMIA International Journal for Chemistry
Publisher
Swiss Chemical Society
Citation
Lathrop, Stephen Paul; Kim, Justin; Movassaghi, Mohammad. Chimia (Aarau). 2012; 66(6): 389–393.
Version
Author's final manuscript
Abstract
Concise and general strategies for radical-based dimerization of cyclotryptamine and cyclotryptophan derivatives in addition to radical-based oxidation of structurally complex diketopiperazines are discussed. The impact of these radical-based chemistries on the rapid generation of molecular complexity is highlighted using representative examples from recent complex homodimeric alkaloid total syntheses. Additionally, a new and general strategy for radical-based directed heterodimerization of cyclotryptamine substructures via solvent-caged unsymmetrical diazene fragmentation is discussed.
Description
The doi doesn't seem to work, but it is the correct one.
MIT Department
Massachusetts Institute of Technology. Department of Chemistry
Terms of Use
Creative Commons Attribution-Noncommercial-Share Alike 3.0
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DOI of Published Version
https://doi.org/10.2533/chimia.2012.389
