Theory of Active Chromatin Remodeling
Name
PhysRevLett.123.208102.pdf
Description
Published version
Size
444.12 KB
Format
Adobe PDF
Checksum (MD5)
e2fe2ca860ddf14ca912f64ab7177ca8
Author(s)
Jiang, Zhongling
Zhang, Bin
Date Issued
November 2019
Journal
Physical Review Letters
Publisher
American Physical Society (APS)
Citation
Jiang, Zhongling and Bin Zhang. "Theory of Active Chromatin Remodeling." Physical Review Letters 123, 20 (November 2019): 208102 © 2019 American Physical Society
Version
Final published version
Abstract
Nucleosome positioning controls the accessible regions of chromatin and plays essential roles in DNA-Templated processes. ATP driven remodeling enzymes are known to be crucial for its establishment in vivo, but their nonequilibrium nature has hindered the development of a unified theoretical framework for nucleosome positioning. Using a perturbation theory, we show that the effect of these enzymes can be well approximated by effective equilibrium models with rescaled temperatures and interactions. Numerical simulations support the accuracy of the theory in predicting both kinetic and steady-state quantities, including the effective temperature and the radial distribution function, in biologically relevant regimes. The energy landscape view emerging from our study provides an intuitive understanding for the impact of remodeling enzymes in either reinforcing or overwriting intrinsic signals for nucleosome positioning, and may help improve the accuracy of computational models for its prediction in silico.
MIT Department
Massachusetts Institute of Technology. Department of Chemistry
Terms of Use
Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
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DOI of Published Version
https://doi.org/10.1103/physrevlett.123.208102
