Aristolochic Acids as Persistent Soil Pollutants: Determination of Risk for Human Exposure and Nephropathy from Plant Uptake
Name
nihms-1015579.pdf
Description
Accepted version
Size
1.75 MB
Format
Adobe PDF
Checksum (MD5)
d13c6232268e413a20b1e33fd90328a0
Author(s)
Dedon, Peter C.
Date Issued
October 5, 2018
Journal
Journal of agricultural and food chemistry
Publisher
American Chemical Society (ACS)
Citation
Li, Weiwei et al. “Aristolochic Acids as Persistent Soil Pollutants: Determination of Risk for Human Exposure and Nephropathy from Plant Uptake.” Journal of agricultural and food chemistry 66 (2018): 11468-11476 © 2018 The Author(s)
Version
Author's final manuscript
Abstract
Exposure to aristolochic acids (AAs) from Aristolochia plants is one of the major global causes of nephropathy, including Balkan endemic nephropathy (BEN); renal failure; and urothelial cancer. The high incidence of BEN on the Balkan Peninsula is assumed to result from consumption of Aristolochia clematitis L. seeds coharvested with crops. Here, we show that AAs are long-lived soil contaminants that enter wheat and maize plants by root uptake with strong pH dependence. Soil and crops from Serbian farms in areas endemic for A. clematitis were found to be extensively contaminated with AAs, with contamination strongly correlated with local incidence of BEN. The persistence of AAs as soil contaminants suggests that weed control for A. clematitis plants is needed to reduce the incidence of BEN and aristolochic acid nephropathy, systematic surveys of soil and crop AA levels would identify high-risk regions, and it is imperative to research soil-remediation methods.
Subjects
General Chemistry
General Agricultural and Biological Sciences
MIT Department
Massachusetts Institute of Technology. Department of Biological Engineering
Terms of Use
Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
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DOI of Published Version
https://doi.org/10.1021/acs.jafc.8b04770
