Human nerve distribution and density around the carotid artery bifurcation
Name
392_2024_Article_2419.pdf
Size
1.59 MB
Format
Adobe PDF
Checksum (MD5)
cdabf374f5a6288c58272a7a04182234
Author(s)
Struthoff, Helge
Lauder, Lucas
Federspiel, Jan M.
Hohl, Mathias
Böhm, Michael
Tschernig, Thomas
Mahfoud, Felix
Date Issued
February 26, 2024
Journal
Clinical Research in Cardiology
Publisher
Springer Science and Business Media LLC
Citation
Struthoff, H., Lauder, L., Federspiel, J.M. et al. Human nerve distribution and density around the carotid artery bifurcation. Clin Res Cardiol (2024).
Version
Final published version
Abstract
Modulation of the autonomic nervous system represents an attractive treatment target for cardiovascular diseases, including hypertension, heart failure and atrial fibrillation [1]. Stretch-sensitive baroreceptors in the carotid sinus contribute to short- and long-term blood pressure regulation. Increased wall strain due to high blood pressure increases the activity of arterial baroreceptors and thereby reduces sympathetic outflow and total peripheral resistance [3, 5]. Stimulation of the carotid baroreflex using electrical properties or a stent-like device is currently under clinical investigation in heart failure and hypertension [1]. Detailed knowledge about the nerves running along the carotid arteries is essential to identify attractive treatment targets and locations and to further refine existing technologies and techniques. Here, we analyzed the nerves traveling along the human carotid arteries.
Subjects
Cardiology and Cardiovascular Medicine
General Medicine
MIT Department
Massachusetts Institute of Technology. Institute for Medical Engineering & Science
Terms of Use
Creative Commons Attribution
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1007/s00392-024-02419-0
