Personalized Radiation Attenuating Materials for Gastrointestinal Mucosal Protection
Name
Advanced Science - 2021 - Byrne - Personalized Radiation Attenuating Materials for Gastrointestinal Mucosal Protection.pdf
Description
Published version
Size
3.15 MB
Format
Adobe PDF
Checksum (MD5)
02d45d1ce6494a55969f48a6f9563bea
Author(s)
Byrne, James D
Young, Cameron C
Chu, Jacqueline N
Pursley, Jennifer
Chen, Mu Xian
Wentworth, Adam J
Feng, Annie
Kirtane, Ameya R
Remillard, Kyla A
Hancox, Cindy I
Date Issued
2021
Journal
Advanced Science
Publisher
Wiley
Citation
Byrne, James D, Young, Cameron C, Chu, Jacqueline N, Pursley, Jennifer, Chen, Mu Xian et al. 2021. "Personalized Radiation Attenuating Materials for Gastrointestinal Mucosal Protection." Advanced Science, 8 (12).
Version
Final published version
Abstract
Cancer patients undergoing therapeutic radiation routinely develop injury of the adjacent gastrointestinal (GI) tract mucosa due to treatment. To reduce radiation dose to critical GI structures including the rectum and oral mucosa, 3D-printed GI radioprotective devices composed of high-Z materials are generated from patient CT scans. In a radiation proctitis rat model, a significant reduction in crypt injury is demonstrated with the device compared to without (p < 0.0087). Optimal device placement for radiation attenuation is further confirmed in a swine model. Dosimetric modeling in oral cavity cancer patients demonstrates a 30% radiation dose reduction to the normal buccal mucosa and a 15.2% dose reduction in the rectum for prostate cancer patients with the radioprotectant material in place compared to without. Finally, it is found that the rectal radioprotectant device is more cost-effective compared to a hydrogel rectal spacer. Taken together, these data suggest that personalized radioprotectant devices may be used to reduce GI tissue injury in cancer patients undergoing therapeutic radiation.
MIT Department
Koch Institute for Integrative Cancer Research at MIT
Massachusetts Institute of Technology. Department of Mechanical Engineering
Massachusetts Institute of Technology. Division of Comparative Medicine
Terms of Use
Creative Commons Attribution 4.0 International license
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1002/ADVS.202100510
