A regulatory variant at 3q21.1 confers an increased pleiotropic risk for hyperglycemia and altered bone mineral density
Name
1-s2.0-S1550413121000012-main.pdf
Description
Published version
Size
3.21 MB
Format
Unknown
Checksum (MD5)
0ad5e77238af7df8fd535aaa80e0e4b6
Author(s)
Sinnott-Armstrong, Nasa
Sousa, Isabel S.
Laber, Samantha
Rendina-Ruedy, Elizabeth
Nitter Dankel, Simon E.
Ferreira, Teresa
Mellgren, Gunnar
Karasik, David
Rivas, Manuel
Pritchard, Jonathan
Date Issued
March 2021
Journal
Cell Metabolism
Publisher
Elsevier BV
Version
Final published version
Abstract
Nasa Sinnott-Armstrong and colleagues identify a pleiotropic risk locus at 3q21 that is associated with type 2 diabetes (T2D) and greater bone mineral density (BMD) and its associated cell-autonomous mechanisms in adipocytes and osteoblasts. Together, these findings provide a possible explanation for the perplexing finding that individuals with T2D have higher BMD but greater susceptibility to bone fracture.
MIT Department
Massachusetts Institute of Technology. Department of Biology
Terms of Use
Creative Commons Attribution 4.0 International license
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1016/j.cmet.2021.01.001
