Assessment of ion-selective optical nanosensors for drug screening applications
Name
227814259-MIT.pdf
Description
Full printable version
Size
3.53 MB
Format
Adobe PDF
Checksum (MD5)
fec30a273d7c8738ddbc9d0db606b2d8
Author(s)
Yun, Hannah
Advisor(s)
Heather A. Clark.
Date Issued
2007
Publisher
Massachusetts Institute of Technology
Abstract
Ion channels represent an important category of drug targets. They play a significant role in numerous physiological functions, from membrane excitation and signaling to fluid absorption and secretion. An ion-channel assay system using optical nanosensors has recently been developed. This high-throughput, high-content system improves on the existing patch clamp and fluorescent dye technologies that presently dominate the ion-channel screening market. This paper introduces the nanosensor technology, reviews the current market for ion-channel assays, assesses the costs associated with the nanosensors, and evaluates their commercialization potential.
Description
Thesis (M. Eng.)--Massachusetts Institute of Technology, Dept. of Materials Science and Engineering, 2007.
"September 2007."
Includes bibliographical references (p. 67-69).
Subjects
Materials Science and Engineering.
MIT Department
Massachusetts Institute of Technology. Department of Materials Science and Engineering
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