Polymer Fiber Probes Enable Optical Control of Spinal Cord and Muscle Function In Vivo
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Lu-Spinal-Cord-06-10-2014.pdf
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Author(s)
Canales, Andres
Caggiano, Vittorio
Bizzi, Emilio
Anikeeva, Polina Olegovna
Froriep, Ulrich Paul
Koppes, Ryan
Selvidge, Jennifer G.
Lu, Chi, Ph. D. Massachusetts Institute of Technology
Date Issued
August 2014
Journal
Advanced Functional Materials
Publisher
Wiley Blackwell
Citation
Lu, Chi, Ulrich P. Froriep, Ryan A. Koppes, Andres Canales, Vittorio Caggiano, Jennifer Selvidge, Emilio Bizzi, and Polina Anikeeva. “Polymer Fiber Probes Enable Optical Control of Spinal Cord and Muscle Function In Vivo.” Adv. Funct. Mater. 24, no. 42 (August 26, 2014): 6594–6600.
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Author's final manuscript
Abstract
Restoration of motor and sensory functions in paralyzed patients requires the development of tools for simultaneous recording and stimulation of neural activity in the spinal cord. In addition to its complex neurophysiology, the spinal cord presents technical challenges stemming from its flexible fibrous structure and repeated elastic deformation during normal motion. To address these engineering constraints, we developed highly flexible fiber probes, consisting entirely of polymers, for combined optical stimulation and recording of neural activity. The fabricated fiber probes exhibit low-loss light transmission even under repeated extreme bending deformations. Using our fiber probes, we demonstrate simultaneous recording and optogenetic stimulation of neural activity in the spinal cord of transgenic mice expressing the light sensitive protein channelrhodopsin 2 (ChR2). Furthermore, optical stimulation of the spinal cord with the polymer fiber probes induces on-demand limb movements that correlate with electromyographical (EMG) activity.
MIT Department
Massachusetts Institute of Technology. Department of Materials Science and Engineering
Massachusetts Institute of Technology. Research Laboratory of Electronics
McGovern Institute for Brain Research at MIT
Simons Center for the Social Brain (Massachusetts Institute of Technology)
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DOI of Published Version
https://doi.org/10.1002/adfm.201401266
