UMBRELAA: DESIGN OF A VARIABLE-SIZED LEFT ATRIAL APPENDAGE OCCLUSION DEVICE FOR STROKE PREVENTION
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v001t01a001-dmd2023-1984.pdf
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1.12 MB
Format
Adobe PDF
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cc7a1c779e19da098c59be4a297312a4
Author(s)
Reddie, Madison
Eberly, Gari
Jesse Levi, Aviva
Quevedo-Moreno, Diego
Mendez, Keegan
Roche, Ellen T.
Date Issued
April 17, 2023
Journal
2023 Design of Medical Devices Conference
Publisher
American Society of Mechanical Engineers
Citation
Reddie, M, Eberly, G, Jesse Levi, A, Quevedo-Moreno, D, Mendez, K, & Roche, ET. "UMBRELAA: DESIGN OF A VARIABLE-SIZED LEFT ATRIAL APPENDAGE OCCLUSION DEVICE FOR STROKE PREVENTION." Proceedings of the 2023 Design of Medical Devices Conference. 2023 Design of Medical Devices Conference. Minneapolis, MN, USA. April 17–19, 2023. V001T01A001. ASME.
Version
Final published version
Abstract
Blood clots originating in the left atrial appendage (LAA) are the leading cause of ischemic stroke in patients with nonvalvular atrial fibrillation (AF). Complications from and contraindications to oral anticoagulants (OACs), in addition to the recent successes of endocardial LAA closure devices, have driven increased interest in mechanical LAA occlusion. However, current devices are limited in their abilities to accommodate diverse LAA anatomies, motivating the development of a novel endocardial LAA occluder that supports more anatomical variability. We present the design of an in-situ expandable plug as well as an accompanying pacifier module for LAA occlusion. The final design accommodates LAA diameter ranges of 14 millimeters for each device size (10-24mm and 24-38mm), double that of any approved device. This adaptability can help to overcome imperfect pre-procedural imaging and suboptimal device fit. Benchtop tug and leak tests demonstrate the stability and sealing capacities of the design.
Description
Proceedings of the 2023 Design of Medical Devices Conference DMD2023 April 17-19, 2023, Minneapolis, MN, USA
MIT Department
Massachusetts Institute of Technology. Department of Mechanical Engineering
Harvard University--MIT Division of Health Sciences and Technology
Massachusetts Institute of Technology. Institute for Medical Engineering & Science
Terms of Use
Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1115/dmd2023-1984
