Frequency-specific hippocampal-prefrontal interactions during associative learning
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Miller_Frequency-specific.pdf
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Author(s)
Brincat, Scott Louis
Miller, Earl K.
Date Issued
February 2015
Journal
Nature Neuroscience
Publisher
Nature Publishing Group
Citation
Brincat, Scott L, and Earl K Miller. “Frequency-Specific Hippocampal-Prefrontal Interactions During Associative Learning.” Nat Neurosci 18, no. 4 (February 23, 2015): 576–581.
Version
Author's final manuscript
Abstract
Much of our knowledge of the world depends on learning associations (for example, face-name), for which the hippocampus (HPC) and prefrontal cortex (PFC) are critical. HPC-PFC interactions have rarely been studied in monkeys, whose cognitive and mnemonic abilities are akin to those of humans. We found functional differences and frequency-specific interactions between HPC and PFC of monkeys learning object pair associations, an animal model of human explicit memory. PFC spiking activity reflected learning in parallel with behavioral performance, whereas HPC neurons reflected feedback about whether trial-and-error guesses were correct or incorrect. Theta-band HPC-PFC synchrony was stronger after errors, was driven primarily by PFC to HPC directional influences and decreased with learning. In contrast, alpha/beta-band synchrony was stronger after correct trials, was driven more by HPC and increased with learning. Rapid object associative learning may occur in PFC, whereas HPC may guide neocortical plasticity by signaling success or failure via oscillatory synchrony in different frequency bands.
MIT Department
Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
Picower Institute for Learning and Memory
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Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
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DOI of Published Version
https://doi.org/10.1038/nn.3954
