Transplantation of human islets without immunosuppression
Name
Ludwig-2013-Transplantation of h.pdf
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Author(s)
Colton, Clark K.
Ludwig, Barbara
Reichel, Andreas
Steffen, Anja
Zimerman, Baruch
Schally, Andrew V.
Block, Norman L.
Ludwig, Stefan
Kersting, Stephan
Bonifacio, Ezio
Date Issued
November 2013
Journal
Proceedings of the National Academy of Sciences
Publisher
National Academy of Sciences (U.S.)
Citation
Ludwig, B., A. Reichel, A. Steffen, B. Zimerman, A. V. Schally, N. L. Block, C. K. Colton, et al. “Transplantation of Human Islets Without Immunosuppression.” Proceedings of the National Academy of Sciences 110, no. 47 (October 28, 2013): 19054–19058.
Version
Final published version
Abstract
Transplantation of pancreatic islets is emerging as a successful treatment for type-1 diabetes. Its current stringent restriction to patients with critical metabolic lability is justified by the long-term need for immunosuppression and a persistent shortage of donor organs. We developed an oxygenated chamber system composed of immune-isolating alginate and polymembrane covers that allows for survival and function of islets without immunosuppression. A patient with type-1 diabetes received a transplanted chamber and was followed for 10 mo. Persistent graft function in this chamber system was demonstrated, with regulated insulin secretion and preservation of islet morphology and function without any immunosuppressive therapy. This approach may allow for future widespread application of cell-based therapies.
MIT Department
Massachusetts Institute of Technology. Department of Chemical Engineering
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Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
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DOI of Published Version
https://doi.org/10.1073/pnas.1317561110
