The Initial Hours of Metastasis: The Importance of Cooperative Host-Tumor Cell Interactions during Hematogenous Dissemination
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Hynes_The initial hours.pdf
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1.06 MB
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Adobe PDF
Checksum (MD5)
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Author(s)
Labelle, Myriam
Hynes, Richard O
Date Issued
November 2012
Journal
Cancer Discovery
Publisher
American Association for Cancer Research
Citation
Labelle, M., and R. O. Hynes. “The Initial Hours of Metastasis: The Importance of Cooperative Host-Tumor Cell Interactions during Hematogenous Dissemination.” Cancer Discovery 2, no. 12 (December 9, 2012): 1091-1099.
Version
Author's final manuscript
Abstract
Tumor cells transit from the primary tumor via the blood circulation to form metastases in distant organs. During this process, tumor cells encounter a number of environmental challenges and stimuli that profoundly impact their metastatic potential. Here, we review the cooperative and dynamic host–tumor cell interactions that support and promote the hematogenous dissemination of cancer cells to sites of distant metastasis. In particular, we discuss what is known about the cross-talk occurring among tumor cells, platelets, leukocytes, and endothelial cells and how these cell–cell interactions are organized both temporally and spatially at sites of extravasation and in the early metastatic niche.
MIT Department
Massachusetts Institute of Technology. Department of Biology
Koch Institute for Integrative Cancer Research at MIT
Terms of Use
Creative Commons Attribution-Noncommercial-Share Alike 3.0
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DOI of Published Version
https://doi.org/10.1158/2159-8290.cd-12-0329
