Aberrant Development and Plasticity of Excitatory Visual Cortical Networks in the Absence of cpg15
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Picard-2014-Aberrant Development.pdf
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Author(s)
Picard, Nathalie
Leslie, Jennifer H.
Trowbridge, Sara Kishi
Subramanian, Jaichandar
Nedivi, Elly
Fagiolini, Michela
Date Issued
March 2014
Journal
Journal of Neuroscience
Publisher
Society for Neuroscience
Citation
Picard, N., J. H. Leslie, S. K. Trowbridge, J. Subramanian, E. Nedivi, and M. Fagiolini. “Aberrant Development and Plasticity of Excitatory Visual Cortical Networks in the Absence of Cpg15.” Journal of Neuroscience 34, no. 10 (March 5, 2014): 3517–3522.
Version
Final published version
Abstract
During development, experience plays a crucial role in sculpting neuronal connections. Patterned neural activity guides formation of functional neural circuits through the selective stabilization of some synapses and the pruning of others. Activity-regulated factors are fundamental to this process, but their roles in synapse stabilization and maturation is still poorly understood. CPG15, encoded by the activity-regulated gene candidate plasticity gene 15, is a small, glycosylphosphatidylinositol (GPI)-linked, extracellular protein that promotes synapse stabilization. Here we show that global knock-out of cpg15 results in abnormal postnatal development of the excitatory network in visual cortex and an associated disruption in development of visual receptive field properties. In addition, whereas repeated stimulation induced potentiation and depression in wild-type mice, the depression was slower in cpg15 knock-out mice, suggesting impairment in short-term depression-like mechanisms. These findings establish the requirement for cpg15 in activity-dependent development of the visual system and demonstrate the importance of timely excitatory network development for normal visual function.
MIT Department
Harvard University--MIT Division of Health Sciences and Technology
Massachusetts Institute of Technology. Department of Biology
Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
Picower Institute for Learning and Memory
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Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
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DOI of Published Version
https://doi.org/10.1523/jneurosci.2955-13.2014
