Tortuous Pore Path Through the Glaucomatous Lamina Cribrosa
Name
s41598-018-25645-9.pdf
Description
Published version
Size
1.56 MB
Format
Adobe PDF
Checksum (MD5)
3aeae7e970dd5a160418356155bc755f
Author(s)
Wang, Bo
Lucy, Katie A.
Schuman, Joel S.
Sigal, Ian A.
Bilonick, Richard A.
Lu, Chen
Liu, Jonathan Jaoshin
Grulkowski, Ireneusz
Nadler, Zachary
Ishikawa, Hiroshi
Date Issued
May 2018
Journal
Scientific Reports
Publisher
Springer Science and Business Media LLC
Citation
Wang, Bo et al. "Tortuous Pore Path Through the Glaucomatous Lamina Cribrosa." Scientific Reports 8 (May 2018): 7281 © 2018 The Author(s)
Version
Final published version
Abstract
The lamina cribrosa is a primary site of damage in glaucoma. While mechanical distortion is hypothesized to cause reduction of axoplasmic flow, little is known about how the pores, which contains the retinal ganglion cell axons, traverse the lamina cribrosa. We investigated lamina cribrosa pore paths in vivo to quantify differences in tortuosity of pore paths between healthy and glaucomatous eyes. We imaged 16 healthy, 23 glaucoma suspect and 48 glaucomatous eyes from 70 subjects using a swept source optical coherence tomography system. The lamina cribrosa pores were automatically segmented using a previously described segmentation algorithm. Individual pore paths were automatically tracked through the depth of the lamina cribrosa using custom software. Pore path convergence to the optic nerve center and tortuosity was quantified for each eye. We found that lamina cribrosa pore pathways traverse the lamina cribrosa closer to the optic nerve center along the depth of the lamina cribrosa regardless of disease severity or diagnostic category. In addition, pores of glaucoma eyes take a more tortuous path through the lamina cribrosa compared to those of healthy eyes, suggesting a potential mechanism for reduction of axoplasmic flow in glaucoma.
MIT Department
Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science
Massachusetts Institute of Technology. Research Laboratory of Electronics
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Creative Commons Attribution 4.0 International license
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DOI of Published Version
https://doi.org/10.1038/s41598-018-25645-9
