Microfluidic vascular models of tumor cell extravasation
Name
fonc-12-1052192.pdf
Size
1.51 MB
Format
Adobe PDF
Checksum (MD5)
6e2dfbd25dd7e8735c03d5bedb15c8f3
Author(s)
Kim, Seunggyu
Wan, Zhengpeng
Jeon, Jessie S.
Kamm, Roger D.
Date Issued
November 11, 2022
Publisher
Frontiers Media SA
Citation
Kim, Seunggyu, Wan, Zhengpeng, Jeon, Jessie S. and Kamm, Roger D. 2022. "Microfluidic vascular models of tumor cell extravasation." 12.
Version
Final published version
Abstract
Emerging microfluidic disease models have amply demonstrated their value in many fields of cancer research. These in vitro technologies recapitulate key aspects of metastatic cancer, including the process of tumor cell arrest and extravasation at the site of the metastatic tumor. To date, extensive efforts have been made to capture key features of the microvasculature to reconstitute the pre-metastatic niche and investigate dynamic extravasation behaviors using microfluidic systems. In this mini-review, we highlight recent microfluidic vascular models of tumor cell extravasation and explore how this approach contributes to development of in vitro disease models to enhance understanding of metastasis in vivo.
Subjects
Cancer Research
Oncology
MIT Department
Massachusetts Institute of Technology. Mechanobiology Laboratory
Massachusetts Institute of Technology. Department of Mechanical Engineering
Terms of Use
Creative Commons Attribution 4.0 International license
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.3389/fonc.2022.1052192
