Quantitative linkage of physiology and gene expression through empirical model construction: an investigation of diabetes
Name
MEBCS023.pdf
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209.08 KB
Format
Adobe PDF
Checksum (MD5)
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Author(s)
Misra, J.
Alevizos, I.
Bullen, J.
Blueher, S.
Mantzoros, C.
Stephanopoulos, Gregory
Date Issued
January 2003
Series/Report no.
Molecular Engineering of Biological and Chemical Systems (MEBCS);
Abstract
A methodology for the construction of predictive empirical models of physiological characteristics from microarray data is presented. The method, applied here to the study of the development of diabetes and insulin resistance, can be further expanded to other cases and to also include a variety of other data, such as protein expression, or metabolic flux data. The importance of several of the genes identified by the modeling methodology can be verified by comparison with results from prior literature. This implies potentially significant roles in diabetes for several of the uncharacterized genes discovered during the modeling procedure.
Subjects
diabetes
microarrays
partial least squares
systems biology
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