Genome-scale neurogenetics: methodology and meaning
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nihms-793860(1).pdf
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Author(s)
McCarroll, Steven A
Feng, Guoping
Hyman, Steven E
Date Issued
May 2014
Journal
Nature Neuroscience
Publisher
Nature Publishing Group
Citation
McCarroll, Steven A et al. “Genome-Scale Neurogenetics: Methodology and Meaning.” Nature Neuroscience 17, 6 (May 2014): 756–763 © 2014 Nature America, Inc
Version
Author's final manuscript
Abstract
Genetic analysis is currently offering glimpses into molecular mechanisms underlying such neuropsychiatric disorders as schizophrenia, bipolar disorder and autism. After years of frustration, success in identifying disease-associated DNA sequence variation has followed from new genomic technologies, new genome data resources, and global collaborations that could achieve the scale necessary to find the genes underlying highly polygenic disorders. Here we describe early results from genome-scale studies of large numbers of subjects and the emerging significance of these results for neurobiology.
MIT Department
Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
McGovern Institute for Brain Research at MIT
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Creative Commons Attribution-Noncommercial-Share Alike
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DOI of Published Version
https://doi.org/10.1038/NN.3716
