Continuous manufacturing – the Green Chemistry promise?
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c9gc00773c.pdf
Size
4.83 MB
Format
Adobe PDF
Checksum (MD5)
0c89fad3b8e148c8ac90ae87a16d22db
Author(s)
Rogers, Luke
Jensen, Klavs F.
Date Issued
May 2019
Journal
Green chemistry
Publisher
Royal Society of Chemistry (RSC)
Citation
Rogers, Luke, and Klavs F. Jensen, "Continuous manufacturing – the Green Chemistry promise?" Green chemistry 13 (May 2019): p. 3481-98 doi 10.1039/c9gc00773c ©2019 Author(s)
Version
Final published version
Abstract
Continuous manufacturing and Green Chemistry, are two promising approaches to synthesis with underutilized potential that are gaining traction by the wider pharmaceutical community. We review Green Chemistry advances resulting when transitioning to continuous manufacturing with focus on Green Chemistry elements inherent in flow chemistry and related separation processes. Case studies of continuous manufacturing represented by the F3 (Flexible, Fast, and Future) project, cGPM manufacturing at Eli Lilly, and the MIT pharmaceuticals on demand projects provide examples of Green Chemistry advances realised. Throughout the review, Green Chemistry advances are identified in terms of the pertinent principles of Green Chemistry. A count of the occurrences of the different principles of Green Chemistry reveals that the principle of prevention greatly overshadows all other principles. ©2019
Subjects
Pollution
Environmental Chemistry
MIT Department
Massachusetts Institute of Technology. Department of Chemical Engineering
Terms of Use
Creative Commons Attribution 3.0 unported license
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1039/c9gc00773c
