Combating Obesity With Thermogenic Fat: Current Challenges and Advancements
Name
fendo-11-00185.pdf
Description
Published version
Size
597.36 KB
Format
Adobe PDF
Checksum (MD5)
32a92356d99da18386854a39027713dd
Author(s)
Pan, Ruping
Zhu, Xiaohua
Maretich, Pema
Chen, Yong
Date Issued
April 15, 2020
Journal
Frontiers in Endocrinology
Publisher
Frontiers Media SA
Citation
Pan R, Zhu X, Maretich P and Chen Y (2020) Combating Obesity With Thermogenic Fat: Current Challenges and Advancements. Front. Endocrinol. 11:185.
Version
Final published version
Abstract
Brown fat and beige fat are known as thermogenic fat due to their contribution to non-shivering thermogenesis in mammals following cold stimulation. Beige fat is unique due to its origin and its development in white fat. Subsequently, both brown fat and beige fat have become viable targets to combat obesity. Over the last few decades, most therapeutic strategies have been focused on the canonical pathway of thermogenic fat activation via the β3-adrenergic receptor (AR). Notwithstanding, administering β3-AR agonists often leads to side effects including hypertension and particularly cardiovascular disease. It is thus imperative to search for alternative therapeutic approaches to combat obesity. In this review, we discuss the current challenges in the field with respect to stimulating brown/beige fat thermogenesis. Additionally, we include a summary of other newly discovered pathways, including non-AR signaling- and non-UCP1-dependent mechanisms, which could be potential targets for the treatment of obesity and its related metabolic diseases.
MIT Department
Massachusetts Institute of Technology. Department of Biology
Terms of Use
Creative Commons Attribution
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.3389/fendo.2020.00185
