Photoswitchable Nanoparticles for Triggered Tissue Penetration and Drug Delivery
Name
Ton-2012-Photoswitchable Nanoparticles for Triggered Tissue Penetration and Drug Delivery.pdf
Size
4.2 MB
Format
Adobe PDF
Checksum (MD5)
732b96c42fc4a501dabbdc2869935196
Author(s)
Tong, Rong
Hemmati, Houman D.
Kohane, Daniel S.
Langer, Robert S
Date Issued
March 2012
Journal
Journal of the American Chemical Society
Citation
Tong, Rong, Houman D. Hemmati, Robert Langer, and Daniel S. Kohane 2012 "Photoswitchable Nanoparticles for Triggered Tissue Penetration and Drug Delivery." Journal of the American Chemical Society 134(21): 8848–8855. © 2012 American Chemical Society.
Version
Final published version
Abstract
We report a novel nanoparticulate drug delivery system that undergoes reversible volume change from 150 to 40 nm upon phototriggering with UV light. The volume change of these monodisperse nanoparticles comprising spiropyran, which undergoes reversible photoisomerization, and PEGylated lipid enables repetitive dosing from a single administration and enhances tissue penetration. The photoswitching allows particles to fluoresce and release drugs inside cells when illuminated with UV light. The mechanism of the light-induced size switching and triggered-release is studied. These particles provide spatiotemporal control of drug release and enhanced tissue penetration, useful properties in many disease states including cancer.
MIT Department
Massachusetts Institute of Technology. Department of Chemical Engineering
Koch Institute for Integrative Cancer Research at MIT
Terms of Use
Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
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DOI of Published Version
https://doi.org/10.1021/ja211888a
