Microfluidic platforms for mechanobiology
Name
Kamm_Microfluidic platforms.pdf
Size
2.47 MB
Format
Adobe PDF
Checksum (MD5)
d302dbde662a53ac0fa4d539e04a1b0b
Author(s)
Li, Ran
Polacheck, William Joseph
Uzel, Sebastien GM
Kamm, Roger Dale
Date Issued
April 2013
Journal
Lab on a Chip
Publisher
Royal Society of Chemistry, The
Citation
Polacheck, William J., Ran Li, Sebastien G. M. Uzel, and Roger D. Kamm. “Microfluidic platforms for mechanobiology.” Lab on a Chip 13, no. 12 (2013): 2252. © Royal Society of Chemistry
Version
Final published version
Abstract
Mechanotransduction has been a topic of considerable interest since early studies demonstrated a link between mechanical force and biological response. Until recently, studies of fundamental phenomena were based either on in vivo experiments with limited control or direct access, or on large-scale in vitro studies lacking many of the potentially important physiological factors. With the advent of microfluidics, many of the previous limitations of in vitro testing were eliminated or reduced through greater control or combined functionalities. At the same time, imaging capabilities were tremendously enhanced. In this review, we discuss how microfluidics has transformed the study of mechanotransduction. This is done in the context of the various cell types that exhibit force-induced responses and the new biological insights that have been elucidated. We also discuss new microfluidic studies that could produce even more realistic models of in vivo conditions by combining multiple stimuli or creating a more realistic microenvironment.
MIT Department
Massachusetts Institute of Technology. Department of Biological Engineering
Massachusetts Institute of Technology. Department of Mechanical Engineering
Terms of Use
Article is available under a Creative Commons license
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1039/c3lc41393d
