Bioresponsive Mesoporous Silica Nanoparticles for Triggered Drug Release
Name
Singh-2011-Bioresponsive Mesoporous Silica Nanoparticles.pdf
Size
2.8 MB
Format
Adobe PDF
Checksum (MD5)
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Author(s)
Singh, Neetu
Karambelkar, Amrita D.
Gu, Luo
Lin, Kevin Yu-Ming
Miller, Jordan S.
Chen, Christopher S.
Sailor, Michael J.
Bhatia, Sangeeta N.
Date Issued
November 2011
Journal
Journal of the American Chemical Society
Publisher
American Chemical Society (ACS)
Citation
Singh, Neetu et al. “Bioresponsive Mesoporous Silica Nanoparticles for Triggered Drug Release.” Journal of the American Chemical Society 133.49 (2011): 19582-19585. © 2011 American Chemical Society
Version
Final published version
Abstract
Mesoporous silica nanoparticles (MSNPs) have garnered a great deal of attention as potential carriers for therapeutic payloads. However, achieving triggered drug release from MSNPs in vivo has been challenging. Here, we describe the synthesis of stimulus-responsive polymer-coated MSNPs and the loading of therapeutics into both the core and shell domains. We characterize MSNP drug-eluting properties in vitro and demonstrate that the polymer-coated MSNPs release doxorubicin in response to proteases present at a tumor site in vivo, resulting in cellular apoptosis. These results demonstrate the utility of polymer-coated nanoparticles in specifically delivering an antitumor payload.
MIT Department
Harvard University--MIT Division of Health Sciences and Technology
Massachusetts Institute of Technology. Department of Chemical Engineering
Terms of Use
Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
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DOI of Published Version
https://doi.org/10.1021/ja206998x
