Tissue- and Organ-Selective Biodistribution of NIR Fluorescent Quantum Dots
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Bawendi_Tissue- and organ-selective.pdf
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Author(s)
Choi, Hak Soo
Ipe, Binil Itty
Misra, Preeti
Lee, Jeong Heon
Bawendi, Moungi G.
Frangioni, John V.
Date Issued
May 2009
Journal
Nano Letters
Publisher
American Chemical Society (ACS)
Citation
Choi, Hak Soo, Binil Itty Ipe, Preeti Misra, Jeong Heon Lee, Moungi G. Bawendi, and John V. Frangioni. “Tissue- and Organ-Selective Biodistribution of NIR Fluorescent Quantum Dots.” Nano Letters 9, no. 6 (June 10, 2009): 2354-2359.
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Author's final manuscript
Abstract
A significant portion of the field of nanomedicine is predicated on being able to target nanoparticles to sites of disease. However, in vivo biodistribution and clearance of nanoparticles are poorly understood. In this study, a novel formulation of near-infrared fluorescent InAs(ZnS) quantum dots was synthesized and coated with a systematically increasing chain length of PEG. We found that varying PEG chain length resulted in major changes in organ/tissue-selective biodistribution and clearance from the body.
MIT Department
Massachusetts Institute of Technology. Department of Chemistry
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DOI of Published Version
https://doi.org/10.1021/nl900872r
