Versatile Enantioselective Synthesis of Functionalized Lactones via Copper-Catalyzed Radical Oxyfunctionalization of Alkenes
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Buchwald_Versatile Enantioselective.pdf
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Author(s)
Zhu, Rong
Buchwald, Stephen Leffler
Date Issued
June 2015
Journal
Journal of the American Chemical Society
Publisher
American Chemical Society (ACS)
Citation
Zhu, Rong, and Stephen L. Buchwald. "Versatile Enantioselective Synthesis of Functionalized Lactones via Copper-Catalyzed Radical Oxyfunctionalization of Alkenes." Journal of the American Chemical Society 137, no. 25 (July 2015): 8069–8077.
Version
Final published version
Abstract
A versatile method for the rapid synthesis of diverse enantiomerically enriched lactones has been developed based on Cu-catalyzed enantioselective radical oxyfunctionalization of alkenes. The scope of this strategy encompasses a series of enantioselective difunctionalization reactions: oxyazidation, oxysulfonylation, oxyarylation, diacyloxylation, and oxyalkylation. These reactions provide straightforward access to a wide range of useful chiral lactone building blocks containing tetrasubstituted stereogenic centers, which are hard to access traditionally.
MIT Department
Massachusetts Institute of Technology. Department of Chemistry
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Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
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DOI of Published Version
https://doi.org/10.1021/jacs.5b04821
