Tumor cell migration in complex microenvironments
Name
Kamm_Tumor cell.pdf
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2.66 MB
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Adobe PDF
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80a8bd7c4d98b074753398b879761c81
Author(s)
Polacheck, William Joseph
Zervantonakis, Ioannis K.
Kamm, Roger Dale
Date Issued
August 2012
Journal
Cellular and Molecular Life Sciences
Publisher
Springer-Verlag
Citation
Polacheck, William J., Ioannis K. Zervantonakis, and Roger D. Kamm. “Tumor Cell Migration in Complex Microenvironments.” Cell. Mol. Life Sci. 70, no. 8 (April 2013): 1335–1356.
Version
Author's final manuscript
Abstract
Tumor cell migration is essential for invasion and dissemination from primary solid tumors and for the establishment of lethal secondary metastases at distant organs. In vivo and in vitro models enabled identification of different factors in the tumor microenvironment that regulate tumor progression and metastasis. However, the mechanisms by which tumor cells integrate these chemical and mechanical signals from multiple sources to navigate the complex microenvironment remain poorly understood. In this review, we discuss the factors that influence tumor cell migration with a focus on the migration of transformed carcinoma cells. We provide an overview of the experimental and computational methods that allow the investigation of tumor cell migration, and we highlight the benefits and shortcomings of the various assays. We emphasize that the chemical and mechanical stimulus paradigms are not independent and that crosstalk between them motivates the development of new assays capable of applying multiple, simultaneous stimuli and imaging the cellular migratory response in real-time. These next-generation assays will more closely mimic the in vivo microenvironment to provide new insights into tumor progression, inform techniques to control tumor cell migration, and render cancer more treatable.
MIT Department
Massachusetts Institute of Technology. Department of Biological Engineering
Massachusetts Institute of Technology. Department of Mechanical Engineering
Terms of Use
Creative Commons Attribution-Noncommercial-Share Alike
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DOI of Published Version
https://doi.org/10.1007/s00018-012-1115-1
